The tour is supposedly inspired by "The Bad Girl" by Mario Vargas Llosa and the book chronicles the locations of Lima, Paris, London, Tokyo and Madrid, so I can forsee Madame X in these settings.
As for the setlist, I'd like five acts based on the sound of the album: latin-disco-fado-trap-artpop.
Act 1: Latin music
Intro: Madame X manifesto with excerpts of Who's That Girl?
01. Medellín.
02. La Isla Bonita.
03. Faz Gostoso.
04. Batuka.
Act II: House-disco
05. Vogue / I Don't Search I Find.
06. Rescue Me.
07. God Control.
08. Hung Up.
Act III: Fado / Acoustic section
09. Like A Virgin.
10. Crazy.
11. *Audience Requested Song*.
Act 3: Trap-urban
Interlude: Extreme Occident.
12. Human Nature.
13. Future / Unapologetic Bitch.
14. Come Alive.
15. Crave.
Act 4: Art pop
Interlude: .
16. Dark Ballet.
17. Frozen.
18. I Rise.
19. Like A Prayer.
Encore:
20. Bitch, I'm Madonna (Remix).
21. Music.